Tomohisa Okada, M.D., Ph.D.

Research Overview

We provide technical assistance and engages in research and development for non-invasive experiments for humans and animals using 7 Tesla and 3 Tesla magnetic resonance imaging (MRI) systems. We also offer a “Commissioned Test” service to external parties. The MRI measurements include functional MRI, structural imaging including DTI and QSM, and MRS for measuring neurochemicals like glutamate and GABA. Additionally, various stimulus presentation devices (projectors, earphones, electrical stimulators, etc.) are available, and we can record participants’ responses and physiological states, such as button-press responses, heart rate, respiration, pupil diameter, eye movement, etc.

For companies and researchers outside of RIKEN

For researchers from outside RIKEN, MRI experiments can be performed as Commissioned tests. For more details, please refer to the following website:
Commissioned tests (only available in Japanese).

Main Research Fields

Medicine, Dentistry & Pharmacy

Related Research Fields

Biology / Functional neuroimaging / Diagnostic imaging / Medical imaging

Keywords

• Functional magnetic resonance imaging
• Noninvasive measurement of the brain

Research Resources Division(RRD)

• Support Unit for Animal Resources Development (Kimie Niimi, D.V.M., Ph.D.)
• Support Unit for Bio-Material Analysis (Nobuhiko Miyasaka, Ph.D.)
• Support Unit for Functional Magnetic Resonance Imaging (Tomohisa Okada, M.D., Ph.D.)
• Support Unit for Electron Microscopy Techniques (Yoshiyuki Kubota, Ph.D.)

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

1. Ma N, Harasawa N, Ueno K, Cheng K, and Nakahara H.
   "Decision-Making with Predictions of Others' Likely and Unlikely Choices in the Human Brain."
   J Neurosci. 2024 Sep 11;44(37):e2236232024.
2. *Okada T, Kuribayashi H, Urushibata Y, Fujimoto K, Akasaka T, Seethamraju RT, Ahn S, Isa T.
   "GABA, glutamate and excitatory-inhibitory ratios measured using short-TE STEAM MRS at 7-Tesla: Effets of macromolecule basis sets and baseline parameters."
   Heliyon. 2023 Jul 15;9(7):e18357.
3. *Okada T, Fujimoto K, Fushimi Y, Akasaka T, Thuy DHD, Shima A, Sawamoto N, Oishi N, Zhang Z, Funaki T, Nakamoto Y, Murai T, Miyamoto S, Takahashi R, Isa T.
   "Neuroimaging at 7 Tesla: a pictorial narrative review."
   Quant Imaging Med Surg. 2022 Jun;12(6):3406-3435.
4. *Okada T, Handa S, Ding B, Urayama SI, Fujimoto K, Shima A, Yoshii D, Ayaki T, Sawamoto N, Takahashi R, Onoe H, Isa T, Petropoulos L.
   "Insertable inductively coupled volumetric coils for MR microscopy in a human 7T MR system."
   Magn Reson Med. 2022 Mar;87(3):1613-1620.
5. Sakai H, Ueda S, Ueno K, and Kumada T.
   "Neuroplastic Reorganization Induced by Sensory Augmentation for Self-Localization During Locomotion."
   Front Neuroergon. 2021 Aug 13;2:691993.
6. Ueda S, Sakai H, Ueno K, Cheng K, and Kumada T.
   "Cerebellar activation associated with model-based estimation of tool-use consequences."
   Behav Brain Funct. 2019 Apr 16;15(1):8.
7. Nakatani H, Ogawa A, Suzuki C, Asamizuya T, Ueno K, Cheng K, and Okanoya K.
   "Perceived moral traits of others differentiate the neural activation that underlies inequity-aversion."
   Sci Rep. 2017 Feb 23;7:43317.
8. Katahira K, Matsuda YT, Fujimura T, Ueno K, Asamizuya T, Suzuki C, Cheng K, Okanoya K, and Okada M.
   "Neural basis of decision making guided by emotional outcomes."
   J Neurophysiol. 2015 May 1;113(9):3056-68.
9. Sun P, Gardner JL, Costagli M, Ueno K, Waggoner RA, Tanaka K, and Cheng K.
   "Demonstration of tuning to stimulus orientation in the human visual cortex: a high-resolution fMRI study with a novel continuous and periodic stimulation paradigm."
   Cereb Cortex. 2013 Jul;23(7):1618-29.
10. Sun P, Ueno K, Waggoner RA, Gardner JL, Tanaka K, and Cheng K.
    "A temporal frequency-dependent functional architecture in human V1 revealed by high-resolution fMRI."
    Nat Neurosci. 2007 Nov;10(11):1404-6.