Tomohisa Okada, M.D., Ph.D.

Research Overview

We provide technical assistance and engages in research and development for non-invasive experiments for humans and animals using 7 Tesla and 3 Tesla magnetic resonance imaging (MRI) systems. We also offer a "Commissioned Test" service to external parties. The MRI measurements include functional MRI, structural imaging including DTI and QSM, and MRS for measuring neurochemicals like glutamate and GABA. Additionally, various stimulus presentation devices (projectors, earphones, electrical stimulators, etc.) are available, and we can record participants' responses and physiological states, such as button-press responses, heart rate, respiration, pupil diameter, eye movement, etc.

For companies and researchers outside of RIKEN

For researchers from outside RIKEN, even those without collaborative research with RIKEN CBS researchers, MRI experiments can be performed through TRIP (Transformative Research Innovation Platform) platform. For more details, please refer to the following website:
TRIP platform: MRI (only available in Japanese).

Main Research Fields

Biological Sciences

Related Research Fields

Humanities & Social Sciences / Medicine, Dentistry & Pharmacy / Cognitive science-related / Function of nervous system-related / Basic brain sciences-related

Keywords

• Magnetic resonance imaging system
• Brain functional and structural imaging
• Neurochemical measurement
• Neuropsychology
• Cognitive and brain science

Research Resources Division(RRD)

• Support Unit for Animal Resources Development (Kimie Niimi, D.V.M., Ph.D.)
• Support Unit for Bio-Material Analysis (Nobuhiko Miyasaka, Ph.D.)
• Support Unit for Functional Magnetic Resonance Imaging (Tomohisa Okada, M.D., Ph.D.)
• Support Unit for Electron Microscopy Techniques (Chieko Saito, Ph.D.)

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

1. Uji M, Li X, Saotome A, Katsumata R, Waggoner RA, Suzuki C, Ueno K, Aritake S, Tamaki M.
   Human deep sleep facilitates cerebrospinal fluid dynamics linked to spontaneous brain oscillations and neural events.
   Proc Natl Acad Sci U S A. 2025 Oct 14;122(41):e2509626122.
2. Ma N, Harasawa N, Ueno K, Cheng K, Nakahara H.
   Decision-Making with Predictions of Others' Likely and Unlikely Choices in the Human Brain.
   J Neurosci. 2024 Sep 11;44(37):e2236232024.
3. Sakai H, Ueda S, Ueno K, and Kumada T.
   Neuroplastic Reorganization Induced by Sensory Augmentation for Self-Localization During Locomotion.
   Front Neuroergon. 2021 Aug 13;2:691993.
4. Fukuda H, Ma N, Suzuki S, Harasawa N, Ueno K, Gardner JL, Ichinohe N, Haruno M, Cheng K, Nakahara H.
   Computing Social Value Conversion in the Human Brain.
   J Neurosci. 2019 Jun 26;39(26):5153-5172.
5. Ueda S, Sakai H, Ueno K, Cheng K, and Kumada T.
   Cerebellar activation associated with model-based estimation of tool-use consequences.
   Behav Brain Funct. 2019 Apr 16;15(1):8.
6. Nakatani H, Ogawa A, Suzuki C, Asamizuya T, Ueno K, Cheng K, and Okanoya K.
   Perceived moral traits of others differentiate the neural activation that underlies inequity-aversion.
   Sci Rep. 2017 Feb 23;7:43317.
7. Katahira K, Matsuda YT, Fujimura T, Ueno K, Asamizuya T, Suzuki C, Cheng K, Okanoya K, and Okada M.
   Neural basis of decision making guided by emotional outcomes.
   J Neurophysiol. 2015 May 1;113(9):3056-68.
8. Sun P, Gardner JL, Costagli M, Ueno K, Waggoner RA, Tanaka K, and Cheng K.
   Demonstration of tuning to stimulus orientation in the human visual cortex: a high-resolution fMRI study with a novel continuous and periodic stimulation paradigm.
   Cereb Cortex. 2013 Jul;23(7):1618-29.
9. Wan X, Nakatani H, Ueno K, Asamizuya T, Cheng K, Tanaka K.
   The neural basis of intuitive best next-move generation in board game experts.
   Science. 2011 Jan 21;331(6015):341-6.
10. Sun P, Ueno K, Waggoner RA, Gardner JL, Tanaka K, and Cheng K.
    A temporal frequency-dependent functional architecture in human V1 revealed by high-resolution fMRI.
    Nat Neurosci. 2007 Nov;10(11):1404-6.