田中 元雅, Ph.D.

研究内容

当研究チームでは、マウスや酵母などのモデル生物やin vitroの系を用いて、神経科学、構造生物学、遺伝学、プロテオミクスなどの様々な手法から、タンパク質の構造異常が引き起こす神経変性・精神疾患の病態解明、プリオンの形成・伝播における分子構造基盤の解明、さらに、アミロイドなどのタンパク質凝集体の新たな生理機能の発見を目指した研究を展開しています。

研究主分野

総合生物

研究関連分野

医歯薬学

キーワード

• 精神・神経変性疾患
• タンパク質凝集
• アミロイド
• 新生鎖の生物学

主要論文

1. Endo R., Chen Y.K., Burke J., Takashima N., Suryawanshi N., Hui K.K., Miyazaki T., Tanaka M.:
   "Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3."
   Proc. Natl. Acad. Sci. U. S. A., 120, e2211522120 (2023).
   10.1073/pnas.2211522120
2. Nakagawa Y., Shen C-h,, Komi Y., Sugiyama S., Kurinomaru T., Tomabechi Y., Krayukhina E., Okamoto K., Yokoyama T., Shirouzu M., Uchiyama S., Inaba M., Niwa T., Sako Y., Taguchi H., Tanaka M.:
   "Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system."
   Nat. Chem. Biol., 18, 321-331 (2022).
   10.1038/s41589-021-00951-y
3. Shida T., Kamatari Y.O., Yoda T., Yamaguchi Y., Feig M., Ohhashi Y., Sugita Y., Kuwata K., and Tanaka M.:
   "Short disordered protein segment regulates cross-species transmission of a yeast prion."
   Nat. Chem. Biol. 16, 756-765 (2020) (cover article).
   10.1038/s41589-020-0516-y
4. Sugiyama, S., Tanaka, M.:
   "Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis."
   Proc Natl Acad Sci U. S. A., 116, 8909-8918 (2019).
   10.1073/pnas.1819715116
5. Hui, K.K., Takashima, N., Watanabe, A., Chater, T.E., Matsukawa, H., Nekooki-Machida, Y., Nilsson, P., Endo, R., Goda, Y., Saido, T.C., Yoshikawa, T., Tanaka., M.:
   "GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA_A receptor trafficking and social behavior."
   Science Advances, 5(4), eaau8237 (2019).
   10.1126/sciadv.aau8237
6. Endo R., Takashima N., Nekooki-Machida Y., Komi Y., Hui K.K., Takao M., Akatsu H., Murayama S., Sawa A., and Tanaka M.:
   "TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD."
   Biol. Psychiatry, 84, 509-521 (2018).
   10.1016/j.biopsych.2018.03.008
7. Chen  C.W., Tanaka M.
   "Genome-Wide Translation Profiling by Ribosome-Bound tRNA Capture."
   Cell Rep., 23, 608-621 (2018).
   10.1016/j.celrep.2018.03.035
8. Ohhashi Y., Yamaguchi Y., Kurahashi H., Kamatari Y.O., Sugiyama S., Uluca B., Piechatzek T., Komi Y., Shida T., Müller H., Hanashima S., Heise H., Kuwata K, and Tanaka M.
   "Molecular basis for diversification of yeast prion strain conformation,"
   Proc. Natl. Acad. Sci. U. S. A., 115, 2389-2394 (2018).
   10.1073/pnas.1715483115
9. Tanaka, M., Ishizuka, K., Nekooki-Machida, Y., Endo, R., Takashima, N., Sasaki, H., Komi, Y., Gathercole, A., Huston, E., Ishii, K., Hui, K.K., Kurosawa, M., Kim, S.H., Nukina, N.,Takimoto, E., Houslay, M.D., and Sawa, A.:
   "Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease."
   J. Clin. Invest., 127, 1438-1450 (2017).
   10.1172/JCI85594
10. Suzuki, G., Weissman, J.S., and Tanaka, M.:
    "[KIL-d] protein element confers antiviral activity via catastrophic viral mutagenesis."
    Mol. Cell, 60, 651-660 (2015).
    10.1016/j.molcel.2015.10.020