CBS Brain Science Seminar Series(CBSS)
Dr. Guoping Feng
Date/Time
Monday, August 17, 2026, 10:00–11:30 (JST)
Abstract
Neurobiological mechanisms of ASD: from genes to circuits
Human genetic studies have identified a large number of risk genes for autism spectrum disorder (ASD), many of which encode synaptic proteins, suggesting that synaptic dysfunction is a key pathology in ASD. Using a variety of animal models, we have identified distinct synaptic and circuitry mechanisms related to repetitive behaviors, social interaction deficits, sensory abnormalities. Combining single cell transcriptomic analysis and cell type-specific functional manipulation, we have begun to reveal circuit-specific targets for developing potential treatment for some of the debilitating symptoms. In addition, new genome editing technologies allow us to generate non-human primate models and test gene therapy as an effective treatment for monogenic ASD.
Registration
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cbss@ml.riken.jp