CBS Brain Science Seminar Series(CBSS)

Dr. Jan Born

• Institute of Medical Psychology and Behavioral Neurobiology
• University of Tuebingen

Date/Time

Tuesday, October 21, 16:00 (JST)

Abstract

Sleep – a brain state serving memory

Whereas memories are optimally encoded and retrieved when the brain is awake, the consolidation and formation of long-term memory requires an offline mode of processing as optimally established only during sleep. Based on evidence from behavioral and neurobiological studies in humans and rodents, I will consider the formation of long-term memory during sleep as an “active systems consolidation” process in which the repeated neuronal replay of memory representations originating from the hippocampus during slow-wave sleep (SWS) leads to a gradual transformation and integration of representations into extrahippocampal, mainly neocortical networks. I will highlight three features of this process: (i) Hippocampal replay that, by capturing episodic memory aspects, drives consolidation of representations residing inside and outside the hippocampus; (ii) brain oscillations hallmarking SWS and rapid-eye movement (REM) sleep, respectively, which provide mechanisms to regulate both information flow across distant brain networks and local synaptic plasticity; and (iii) qualitative transformations of memories during sleep-dependent systems consolidation resulting in abstract schema-like representations. I will finally go into recent research comparing memory consolidation during sleep with starvation-mediated memory consolidation.

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