服部 信孝, M.D., Ph.D.

研究内容

神経変性疾患連携研究チーム（服部信孝TL）では、神経変性疾患の中でも特にパーキンソン病を対象として、診断や治療を志向した病態解明および創薬探索を行っています。連携先である順天堂大学医学部神経学講座（服部信孝教授）と共同してパーキンソン病の重症度や薬効を評価できるヒト血液バイオマーカー探索や創薬探索を進めております。診断や治療に資する研究を推進し、モデル動物や独自の抗体探索技術を開発して、神経変性疾患の新しい治療法を開発したいと考えています。

研究主分野

医歯薬学

研究関連分野

総合生物 / 神経内科学 / 病態医化学 / 神経生理学・神経科学一般

キーワード

• パーキンソン病
• 神経変性疾患
• 神経炎症
• バイオマーカー
• 機能性抗体

主要論文

「*」は、理研外のみでの成果です。

1. * Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Li Y, Ogaki K, Ando M, Yoshino H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
   CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.
   Lancet Neurol. 2015 Mar;14(3):274-82. doi: 10.1016/S1474-4422(14)70266-2. Epub 2015 Feb 4. PMID: 25662902.
2. * Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Wu YR, Matsuda J, Hattori N.
   Variants in saposin D domain of prosaposin gene linked to Parkinson's disease.
   Brain. 2020 Apr 1;143(4):1190-1205. doi: 10.1093/brain/awaa064. PMID: 32201884.
3. * Saiki S, Hatano T, Fujimaki M, Ishikawa KI, Mori A, Oji Y, Okuzumi A, Fukuhara T, Koinuma T, Imamichi Y, Nagumo M, Furuya N, Nojiri S, Amo T, Yamashiro K, Hattori N.
   Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease.
   Sci Rep. 2017 Aug 4;7(1):7328. doi: 10.1038/s41598-017-06767-y. PMID: 28779141;PMCID: PMC5544708.
4. * Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N.
   Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.
   Neurology. 2018 Jan 30;90(5):e404-e411. doi: 10.1212/WNL.0000000000004888. Epub 2018 Jan 3. PMID: 29298852; PMCID: PMC5791797.
5. * Saiki S, Sasazawa Y, Fujimaki M, Kamagata K, Kaga N, Taka H, Li Y, Souma S, Hatano T, Imamichi Y, Furuya N, Mori A, Oji Y, Ueno SI, Nojiri S, Miura Y, Ueno T, Funayama M, Aoki S, Hattori N.
   A metabolic profile of polyamines in Parkinson disease: A promising biomarker.
   Ann Neurol. 2019 Aug;86(2):251-263. doi: 10.1002/ana.25516. Epub 2019 Jul 1. PMID: 31155745; PMCID: PMC6772170.
6. * Valentine MNZ, Hashimoto K, Fukuhara T, Saiki S, Ishikawa KI, Hattori N, Carninci P.
   Multi-year whole-blood transcriptome data for the study of onset and progression of Parkinson's Disease.
   Sci Data. 2019 Apr 5;6(1):20.
   doi: 10.1038/s41597-019-0022-9. PMID: 30952910; PMCID: PMC6472336.
7. * Okuzumi A, Kurosawa M, Hatano T, Takanashi M, Nojiri S, Fukuhara T, Yamanaka T, Miyazaki H, Yoshinaga S, Furukawa Y, Shimogori T, Hattori N, Nukina N.
   Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment.
   Acta Neuropathol Commun. 2018 Sep 19;6(1):96. doi: 10.1186/s40478-018-0587-0. PMID: 30231908; PMCID: PMC6145187.
8. * Fukuhara T, Kim J, Hokaiwado S, Nawa M, Okamoto H, Kogiso T, Watabe T, Hattori N.
   A novel immunotoxin reveals a new role for CD321 in endothelial cells.
   PLoS One. 2017 Oct 13;12(10):e0181502. doi: 10.1371/journal.pone.0181502. PMID: 29028806; PMCID: PMC5640210.
9. Hamamichi S, Fukuhara T, Hattori N.
   Immunotoxin Screening System: A Rapid and Direct Approach to Obtain Functional Antibodies with Internalization Capacities.
   Toxins (Basel). 2020 Oct 15;12(10):658. doi: 10.3390/toxins12100658. PMID: 33076544; PMCID: PMC7602748.
10. Hamamichi S, Fukuhara T, Umeda IO, Fujii H, Hattori N.
    Novel method for screening functional antibody with comprehensive analysis of its immunoliposome.
    Sci Rep. 2021 Feb 25;11(1):4625. doi: 10.1038/s41598-021-84043-w. PMID: 33633189; PMCID: PMC7907096.