Emi Ling, Ph.D.

脳レジリエンス研究チームチームディレクター

研究内容

人は年齢とともに脳も変化しますが、その老化の進み方には大きな個人差があります。なぜある人は高齢になっても認知機能を保てるのか、その違いはどこから生まれるのか。私たちの研究室では、この問いに分子レベルから挑みます。さらに分子神経生物学、生化学、ゲノミクス、マルチオミクスを統合した学際的アプローチにより、正常な脳老化の個人差を生み出す仕組みを解明するとともに、その理解を支える新しい研究ツールの開発にも取り組みます。これらの研究を通じて、生涯にわたる認知機能の健康維持と加齢性脳疾患の理解に貢献することを目指します。

研究主分野

複合領域

研究関連分野

情報学 / 総合理工 / 総合生物 / 生物学 / 医歯薬学 / 神経科学一般関連 / 病態神経科学関連 / システムゲノム科学関連

キーワード

脳老化
精神神経疾患
オミクス解析
ゲノミクス
個体間変異

主要論文

「*」は、理研外のみでの成果です。

* Ling E §, Nemesh J, Goldman M, Kamitaki N, Reed N, Handsaker RE, Genovese G, Vogelgsang JS, Gerges S, Kashin S, Ghosh S, Esposito JM, Morris K, Meyer D, Lutservitz A, Mullally CD, Wysoker A, Spina L, Neumann A, Hogan M, Ichihara K, Berretta S §#, McCarroll SA §#. (§ = co-corresponding author; # = co-senior author)
"A concerted neuron-astrocyte program declines in ageing and schizophrenia."
Nature 627, 604-611 (2024).
DOI: 10.1038/s41586-024-07109-5
* Yang MG ^, Ling E ^, Cowley CJ, Greenberg ME §, Vierbuchen T §. (^ = co-first author; § = co-corresponding author)
"Characterization of sequence determinants of enhancer function using natural genetic variation."
eLife 11, e76500 (2022).
DOI: 10.7554/eLife.76500
* Ford L ^, Ling E ^, Kandel ER §, Fioriti L §. (^ = co-first author; § = co-corresponding author)
"CPEB3 inhibits translation of mRNA targets by localizing them to P bodies."
PNAS 116, 18078-18087 (2019).
DOI: 10.1073/pnas.1815275116
* Vierbuchen T ^§, Ling E ^, Cowley CJ, Couch CH, Wang X, Harmin DA, Roberts CWM, Greenberg ME. (^ = co-first author; § = corresponding author)
"AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection."
Molecular Cell 68, 1067-1082 (2017).
DOI: 10.1016/j.molcel.2017.11.026
* Yang S, Datta D, Krienen FM, Woo E, May A, Anderson GM, Galvin VC, Gonzalez-Burgos G, Lewis DA, Ling E, McCarroll SA, Arnsten AF, Wang M.
"Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness."
Mol Psychiatry 31, 1190-1200 (2026).
DOI: 10.1038/s41380-025-03425-y
* Datta D, Yang S, Joyce MKP, Woo E, McCarroll SA, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O'Dell R, van Dyck CH, Lewis DA, Wang M, Krienen FM §, Arnsten AFT §. (§ = co-corresponding author)
"Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders."
JAMA Psychiatry 81, 870-881 (2024).
DOI: 10.1001/jamapsychiatry.2024.1112
* Pollina EA ^, Gilliam DT ^, Landau AT, Lin C, Pajarillo N, Davis CP, Harmin DA, Yap EL, Vogel IR, Griffith EC, Nagy MA, Ling E, Duffy EE, Sabatini BL, Weitz CJ, Greenberg ME. (^ = co-first author)
"A NPAS4-NuA4 complex couples synaptic activity to DNA repair."
Nature 614, 732-741 (2023).
DOI: 10.1038/s41586-023-05711-7
* Weiner DJ §, Ling E, Erdin S, Tai DJC, Yadav R, Grove J, Fu JM, Nadig A, Carey CE, Baya N, Bybjerg-Grauholm J, Berretta S, Macosko EZ, Sebat J, O'Connor LJ, Hougaard DM, Børglum AD, Talkowski ME, McCarroll SA, Robinson EB §. (§ = co-corresponding author)
"Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p."
Nat Genet 54, 1630-1639 (2022).
DOI: 10.1038/s41588-022-01203-y
* Stroud H, Yang MG, Tsitohay YN, Davis CP, Sherman MA, Hrvatin S, Ling E, Greenberg ME.
"An Activity-Mediated Transition in Transcription in Early Postnatal Neurons."
Neuron 107, 874-890 (2020).
DOI: 10.1016/j.neuron.2020.06.008
* Cheadle L ^, Tzeng CP ^, Kalish BT, Harmin DA, Rivera S, Ling E, Nagy MA, Hrvatin S, Hu L, Stroud H, Burkly LC, Chen C, Greenberg ME. (^ = co-first author)
"Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement."
Neuron 99, 525-539 (2018).
DOI: 10.1016/j.neuron.2018.06.036