松崎 政紀, Ph.D.

研究内容

小型霊長類マーモセットを用いた高次認知課題や社会性課題を構築し、課題実行中の大脳神経活動動態を高解像度の蛍光イメージング法を用いて計測するとともに、光遺伝学などの手法を用いて神経活動操作をすることで、認知・行動を実現する前頭連合野神経活動動態の原理を明らかにすることを目標に研究を進めています。

研究主分野

総合生物

研究関連分野

情報学 / 総合生物 / 生物学 / 医歯薬学 / 基盤・社会脳科学 / 神経生理学・神経科学一般

キーワード

• 2光子イメージング
• マーモセット
• 前頭葉
• 神経細胞

主要論文

1. Obara K., Ebina T., Terada S., Uka T., Komatsu Y., Takaji M., Watakabe A., Kobayashi K., Masamizu Y., Mizukami H., Yamamori T., Kasai K., Matsuzaki M.:
   “Change detection in the primate auditory cortex through feedback of prediction error signals.”
   Nature Communications 14, 6981, 2023.
   doi: 10.1038/s41467-023-42553-3.
2. Kondo M., Matsuzaki M.:
   “Neuronal representations of reward-predicting cues and outcome history with movement in the frontal cortex.”
   Cell Reports 34, 108704, 2021.
   doi: 10.1016/j.celrep.2021.108704.
3. Matsuzaki M., Ebina T.
   "Common marmoset as a model primate for study of the motor control system."
   Current Opinion in Neurobiology 64, 103-110, 2020.
   10.1016/j.conb.2020.02.013.
4. Ebina T., Obara K., Watakabe A., Masamizu Y., Terada S., Matoba R., Takaji M., Hatanaka A., Nambu A., Mizukami H., Yamamori T., Matsuzaki M.
   "Arm movements induced by non-invasive optogenetic stimulation of the motor cortex in the common marmoset."
   Proc Natl Acad Sci USA 116, 22844-22850, 2019.
   10.1073/pnas.1903445116.
5. *Terada S., Kobayashi K., Ohkura M., Nakai J., Matsuzaki M.
   "Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space."
   Nature Communications 9, 3550, 2018.
   10.1038/s41467-018-06058-8.
6. *Tanaka Y.H., Tanaka Y.R., Kondo M., Terada S., Kawaguchi Y., Matsuzaki M.
   "Thalamocortical axonal activity in motor cortex exhibits layer-specific dynamics during motor learning."
   Neuron 100, 244-258, 2018.
   10.1016/j.neuron.2018.08.016.
7. *Ebina T., Masamizu Y., Tanaka Y.R., Watakabe A., Hirakawa R., Hirayama Y., Hira R., Terada S., Koketsu D., Hikosaka K., Mizukami H., Nambu A., Sasaki E., Yamamori T., Matsuzaki M.
   "Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks."
   Nature Communications 9, 1879, 2018.
   10.1038/s41467-018-04286-6.
8. *Sadakane O., Masamizu Y., Watakabe A., Terada S., Ohtsuka M., Takaji M., Mizukami H., Ozawa K., Kawasaki H., Matsuzaki M., Yamamori T.
   "Long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human primates."
   Cell Reports 13, 1989-1999, 2015.
   10.1016/j.celrep.2015.10.050.
9. *Hira R., Ohkubo F., Masamizu Y., Ohkura M., Nakai J., Okada T., Matsuzaki M.
   "Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning."
   Nature Communications 5, 5551, 2014.
   10.1038/ncomms6551.
10. *Masamizu Y., Tanaka Y.R., Tanaka Y.H., Hira R., Ohkubo F., Kitamura K., Isomura Y., Okada T., Matsuzaki M.
    "Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task."
    Nature Neuroscience 17, 987-994, 2014.
    10.1038/nn.3739.