石田 綾, M.D., Ph.D.

研究内容

生まれて間もない未熟な脳は、外界からの様々な刺激を受け、やがて多彩な機能を発揮する成熟した脳へと変化します。この過程で神経細胞同士のつなぎ目（シナプス）はダイナミックに変化し、成熟したネットワークを生み出します。私たちの研究室では、分子、シナプス、回路と行動を繋ぐ分野横断的なアプローチを用い、脳の生後発達を支える共通原理を明らかにします。ここで確立する技術と知見を発達障害のモデルマウスに応用し、病態の解明と治療開発に貢献することを目指します。

研究主分野

複合領域

研究関連分野

総合生物 / 医歯薬学 / 神経科学（神経生理学・神経科学一般） / 動物生理・行動

キーワード

• 脳発達
• 発達障害
• シナプス
• 神経ネットワーク

主要論文

「*」は、理研外のみでの成果です。

1. * Ito-Ishida A*, Baker SA, Sillitoe RV, Sun Y, Zhou J, Ono Y, Iwakiri J, Yuzaki M, Zoghbi HY*. (* co-corresponding authors)
   “MeCP2 Levels Regulate the 3D Structure of Heterochromatic Foci in Mouse Neurons.”
   Journal of Neuroscience. 40(45), 8746-8766. (2020)
2. * Ito-Ishida A, Yamalanchili HK, Shao Y, Baker SA, Heckman LD, Lavery LA, Kim J, Lombardi LM, Sun Y, Liu Z, Zoghbi HY.
   “Genome Wide Distribution of Linker Histone H1.0 is Independent of MeCP2.”
   Nature Neuroscience. 21(6), 794-798. (2018)
3. * Lu H, Ash RT, He L, Kee SE, Wang W, Yu F, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HY.
   “Loss and gain of MeCP2 lead to similar hippocampal circuit abnormalities that are rescued by deep brain stimulation in a Rett syndrome mouse model.”
   Neuron, 91(4), 739-747. (2016).
4. * Ure K, Lu H, Wang W, Ito-Ishida A, Wu Z, He Y, Sztainberg Y, Tang J, Zoghbi HY.
   “Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett Syndrome.”
   eLife, Jun 21;5:e14198. (2016)
5. * Ito-Ishida A, Ure K, Chen H, Swann JW, Zoghbi HY.
   “Loss of MeCP2 in parvalbumin-and somatostatin-expressing neurons in mice leads to distinct Rett Syndrome-like phenotypes.”
   Neuron. 88(4), 651-8. (2015).
6. * Ito-Ishida A, Kakegawa W, Kohda K, Miura E, Okabe S, Yuzaki M.
   “Cbln1 downregulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells.”
   European Journal of Neuroscience. 39(8), 1268-80. (2014)
7. * Ito-Ishida, A, Miyazaki, T., Miura, E., Matsuda, K., Watanabe, M., Yuzaki, M. and Okabe, S.
   “Presynaptically released Cbln1 induces dynamic axonal structural changes by interacting with GluD2 during cerebellar synapse formation.”
   Neuron 76(3), 549-564. (2012)
8. * Matsuda, K., Miura, E., Miyazaki, T., Kakegawa, W., Emi, K., Narumi, S., Fukazawa, Y., Ito-Ishida, A., Kondo, T., Shigemoto, R., Watanabe, M. and Yuzaki, M.
   “Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer.”
   Science 328(5976): 363-368. (2010)
9. * Ito-Ishida, A, Miura, E., Emi, K., Matsuda, K., Iijima, T., Kondo, T., Kohda, K., Watanabe, M. and Yuzaki, M.
   “Cbln1 regulates rapid formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo.”
   Journal of Neuroscience. 28(23): 5920-5930. (2008)
10. * Ito-Ishida, A., Kakegawa, W. and Yuzaki, M.
    “ERK1/2 but not p38 MAP kinase is essential for the long-term depression in mouse cerebellar slices.”
    European Journal of Neuroscience. 24(6): 1617-1622. (2006)