林（高木）　朗子, M.D., Ph.D.

研究内容

私たちは脳の作動原理、その機能破綻としての精神疾患の研究を行っております。とりわけ傾注するのは、シナプスと言われる構造物で、精神疾患モデル動物におけるシナプス内の分子挙動、シナプス可塑性、そして神経回路を経て行動制御の主体である脳全体に至る多階層システムを理解したいと考えています。さらに、脳機能の解明には既存の技術だけでは不十分だと考えており、新規のイメージング法の開発にも取り組んでいます。こうして、病態生理の因果関係を証明し、それに立脚した治療法を創出することを目指します。

研究主分野

医歯薬学

研究関連分野

総合生物 / 生物学 / 神経科学 / 精神神経科学

キーワード

• 精神疾患
• シナプス
• 多階層
• 2光子励起イメージング

主要論文

「*」は、理研外のみでの成果です。

1. Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R , Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang BK, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto KI, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato XD, Inoue UY, Inoue T, Komine Y, Yamamori T, Sakimura K, Miyakawa T.
   “Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.”
   Elife. 12, e89376. (2024)
2. Temma Y, Obi-Nagata K, Hoshiba Y, Miyake R , Katayama Y, Hagihara H, Suzuki N, Miyakawa T, Nakayama KI, Hayashi-Takagi A
   “Effect of brain acidification on depression-related behaviors in diabetes mellitus.”
   Front. Psychiatry. 14, 1277097. (2023)
3. Obi-Nagata K, Suzuki N, Miyake R , MacDonald ML, Fish KN, Ozawa K, Nagahama K, Okimura T, Tanaka S, Kano M, Fukazawa Y, Sweet RA, Hayashi-Takagi A
   “Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders.”
   Sci. Adv. 9, e5973. (2023)
4. Hayashi-Takagi A
   “To fire or not to fire: decisions mediated by localized processing and dendritic spikes.”
   Nat Rev Neurosci. 24, 194. (2023)
5. Hayashi-Takagi A
   “Constructive understanding of multi-scale dynamism of psychiatric disorders.”
   Neurosci Res. 175, 1-2. (2022)
6. Jo SH, Inoue T, Hayashi-Takagi A
   “Multi-Scale Understanding of NMDA Receptor Function in Schizophrenia.”
   Biomolecules. 10, 1172. (2020)
7. Tsutsumi S, Hayashi-Takagi A
   “Optical interrogation of multi-scale neuronal plasticity underlying behavioral learning.”
   Curr Opin Neurobiol. 67, 8-15. (2020)
8. *Kawamura A, Katayama Y, Nishiyama M, Shoji H, Tokuoka K, Ueta Y, Miyata M, Isa T, Miyakawa T, Hayashi-Takagi A, Nakayama KI.
   “Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice.”
   Hum Mol Genet. 29, 1274-1291. (2020)
9. *Sasaki Y, Oshikawa M, Bharmoria P, Kouno H, Hayashi-Takagi A, Sato M, Ajioka I, Yanai N, Kimizuka N.
   “Near-Infrared Optogenetic Genome Engineering Based on Photon-Upconversion Hydrogels.”
   Angew Chem Int Ed Engl. 58, 17827-17833. (2019)
10. *Obi-Nagata K, Temma Y, Hayashi-Takagi A
    "Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model."
    Proc Jpn Acad Ser B Phys Biol Sci. 95, 179-197. (2019)