We aim to elucidate the molecular, cellular, and neural circuit mechanisms underlying olfactory behaviors.

Yoshihiro Yoshihara

Yoshihiro Yoshihara, Ph.D.

Team Leader, Systems Molecular Ethology
yoshihiro.yoshihara [at] riken.jp

Research Overview

Animals can perceive a huge number of odorants in the external world, which profoundly influence the internal homeostasis and evoke various fundamental behaviors such as food searching, predator avoidance, mate choice, and social interactions. Highly ordered but flexibly modifiable synaptic connections among various types of neurons are the basis of functional logic employed by the brain for sensory information coding and processing. Therefore, detailed knowledge on neuronal connectivity patterns along the olfactory pathways is essential for understanding the wide range of olfactory functions. We aim to clarify the molecular and cellular mechanisms underlying development and functional architecture of the olfactory neural circuits responsible for various odor-evoked behaviors and physiological changes.

Main Research Field

Biological Sciences

Related Research Fields



Selected Publications

  1. Koide T.,Yabuki Y.,and Yoshihara Y.:
    "Terminal nerve GnRH3 neurons mediate slow avoidance of carbon dioxide in larval zebrafish"
    Cell Reports, 22(5), 1115-1123 (2018).
  2. Wakisaka N., Miyasaka N., Koide T., Masuda M., Hiraki-Kajiyama T., and Yoshihara Y.:
    "An adenosine receptor for olfaction in fish"
    Curr. Biol., 27(10), 1437-1447 (2017).
  3. Yabuki Y., Koide T., Miyasaka N., Wakisaka N., Masuda M., Ohkura M., Nakai J., Tsuge K., Tsuchiya S., Sugimoto Y., and Yoshihara Y.:
    "Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior"
    Nat. Neurosci., 19(7), 897-904 (2016).
  4. Miyasaka, N., Arganda-Carreras, I., Wakisaka, N., Masuda, M., Sümbül, U., Seung, H. S., Yoshihara, Y.:
    "Olfactory projectome in the zebrafish forebrain revealed by genetic single-neuron labeling'"
    Nat. Commun., DOI: 10.1038/ncomms4639 (2014).
  5. Kaneko-Goto, T., Sato, Y., Katada, S., Kinameri, E., Yoshihara, S., Nishiyori, A., Kimura, M., Fujita, H., Touhara, K., Reed, R. R., Yoshihara, Y.:
    "Goofy coordinates the acuity of olfactory signaling"
    J. Neurosci., 33, 12987-12996 (2013).
  6. Mizuguchi, R., Naritsuka, H., Mori, K., Mao, C. A., Klein, W. H., Yoshihara, Y.:
    "Tbr2 deficiency in mitral and tufted cells disrupt excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb"
    J. Neurosci., 32, 8831-8844 (2012).
  7. Koide, T., Miyasaka, N., Morimoto, K., Asakawa, A., Urasaki, A., Kawakami, K., Yoshihara, Y.:
    "Olfactory neural circuitry for attraction to amino acids revealed by transposon-mediated gene trap approach in zebrafish"
    Proc. Natl. Acad. Sci. USA, 106, 9884-9889 (2009).
  8. Miyasaka, N., Morimoto, K., Tsubokawa, T., Higashijima, S., Okamoto, H., Yoshihara, Y.:
    "From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish"
    J. Neurosci., 29, 4756-4767 (2009).
  9. Kaneko-Goto, T., Yoshihara, S., Miyazaki, H., Yoshihara, Y.:
    "BIG-2 mediates olfactory axon convergence to target glomeruli"
    Neuron, 57, 834-846 (2008).
  10. Sato, Y., Miyasaka, N., Yoshihara, Y.:
    "Hierarchical regulation of odorant receptor gene choice and subsequent axonal projection of olfactory sensory neurons in zebrafish"
    J. Neurosci., 27, 1606-1615 (2007).

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