Our research aim is to reveal the molecular mechanisms of experience dependent neural circuit development.
Tomomi Shimogori, Ph.D.
Team Leader, Molecular Mechanisms of Brain Development
tomomi.shimogori [at] riken.jp
It is known that adolescent brain development and subsequent brain function are largely affected by the environment and experience. For example, growing up abroad allows children to become bilingual, which is a positive influence on brain function. However, children who have a history of neglect or physical abuse are at risk of developing psychiatric problems. Often these psychiatric problems appear later in their life which makes it difficult to solve and treat the disorder. How are these bad memories 'stored’ and then appear in their later life? One possibility is, under a stressful environment, the maturing child’s brain generates fragile circuits which are not strong enough to survive during adulthood. Therefore, it is important to understand the mechanism of neuronal circuit development which is controlled by environment and experience. In my lab, we are focusing on mouse thalamus-cortex connections to dissect how neuronal circuits are refined by neuronal activity and reveal the molecular mechanisms which underlie it. Moreover, we are trying to understand how the young brain can rewire its circuits to develop cross-modality, and thus compensate for lost connections.
- Shimogori T, Abe A, Go Y, Hashikawa T, Kishi N, Kikuchi SS, Kita Y, Niimi K, Nishibe H, Okuno M, Saga K, Sakurai M, Sato M, Serizawa T, Suzuki S, Takahashi E, Tanaka M, Tatsumoto S, Toki M, U M, Wang Y, Windak KJ, Yamagishi H, Yamashita K, Yoda T, Yoshida AC, Yoshida C, Yoshimoto T, Okano H.:
"Digital gene atlas of neonate common marmoset brain."
Neurosci Res. 128:1-13.(2018)
- Alchini R, Sato H, Matsumoto N, Shimogori T, Sugo N, Yamamoto N.:
"Nucleocytoplasmic Shuttling of Histone Deacetylase 9 Controls Activity-Dependent Thalamocortical Axon Branching."
Sci Rep. 20:6024.(2017)
- Matsui A, Tran M, Yoshida AC, Kikuchi SS, U M, Ogawa M, Shimogori T.:
"BTBD3 controls dendrite orientation toward active axons in mammalian neocortex."
- Mashiko H, Yoshida AC, Kikuchi SS, Niimi K, Takahashi E, Aruga J, Okano H, Shimogori T.:
"Comparative anatomy of marmoset and mouse cortex from genomic expression."
J Neurosci. 32:5039-53.(2012)
- Matsui A, Yoshida AC, Kubota M, Ogawa M and Shimogori T.:
"Mouse in utero electroporation: Controlled spatio-temporal gene transefection."
J Vis Exp. 54 pii:3024.(2011)
- Suzuki-Hirano A, Ogawa M, Kataoka A, Yoshida AC, Itoh D, Ueno M, Blackshaw S, Shimogori T.:
"Dynamic spatiotemporal gene expression in embryonic mouse thalamus."
J Comp Neurol. 519: 528-43.(2011)
- Yuge K, Kataoka A, Yoshida AC, Itoh D, Aggarwal M, Mori S, Blackshaw S, Shimogori T.:
"Region-specific expression in early postnatal mouse thalamus."
J Comp Neurol. 519:544-61.(2011)
- Shimogori T*, Lee DA, Miranda-Angulo A, Yang Y, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, and Blackshaw S*.:
"A genomic atlas of mouse hypothalamic development."
Nat Neurosci. 13:767-75. *corresponding authors.(2010)
- Fukuchi-Shimogori T, Grove EA.:
"Emx2 Patterns the Neocortex by Regulating FGF Positional Signaling."
Nat Neurosci. 8:825-31.(2003)
- Fukuchi-Shimogori T, Grove EA.:
"Neocortex patterning by the secreted signaling molecule FGF8."