Ryoichiro Kageyama, M.D., Ph.D.

Research Overview

We are analyzing the regulatory mechanism of proliferation and differentiation of neural stem cells (NSCs). Embryonic NSCs proliferate intensively and give rise to various types of neurons and glial cells, thereby forming complex brain structures, whereas adult NSCs lose such proliferation and differentiation competencies and therefore cannot regenerate diseased or damaged brain tissues. We aim to elucidate the genetic-level differences between embryonic and adult NSCs and establish the technical basis for brain tissue regeneration.

Main Research Fields

Biological Sciences

Related Research Fields

Biology / Medicine, Dentistry & Pharmacy / Neuroscience / Developmental biology

Keywords

• Neural stem cell
• Neural regeneration
• Adult neurogenesis

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

1. Matsuda, M., Hayashi, H., Garcia-Ojalvo, J., Yoshioka-Kobayashi, K., Kageyama, R., Yamanaka, Y., Ikeya, M., Toguchida, J., Alev, C., and Ebisuya, M.:
   "Species-specific segmentation clock periods are due to differential biochemical reaction speeds."
   Science, 369, 1450-1455 (2020).
2. Yoshioka-Kobayashi, K., Matsumiya, M., Niino, Y., Isomura, A., Kori, H., Miyawaki, A., and Kageyama, R.:
   "Coupling delay controls synchronized oscillation in the segmentation clock."
   Nature 580, 119-123 (2020).
3. Diaz-Cuadros, M., Wagner, D.E., Budjan, C., Hubaud, A., Touboul, J., Michaut, A., Tanoury, Z.A., Yoshioka-Kobayashi, K., Niino, Y., Kageyama, R., Miyawaki, A., and Pourquié, O.:
   "In vitro characterization of the human segmentation clock."
   Nature 580, 113-118 (2020).
4. * Kobayashi, T., Piao, W., Takamura, T., Kori, H., Miyachi, H., Kitano, S., Iwamoto, Y., Yamada, M., Imayoshi, I., Shioda, S., Ballabio, A., and Kageyama, R.:
   "Enhanced lysosomal degradation maintains the quiescent state of neural stem cells."
   Nat. Commun. 10, 5446 (2019).
5. * Sueda, R., Imayoshi, I., Harima, Y., and Kageyama, R.:
   "High Hes1 expression and resultant Ascl1 suppression regulate quiescent versus active neural stem cells in the adult mouse brain."
   Genes Dev. 33, 511-523 (2019).
6. * Kawaguchi, K., Kageyama, R., and Sano, M.:
   "Topological defects control collective dynamics in neural progenitor cell cultures."
   Nature 545, 327-331 (2017).
7. * Isomura, A., Ogushi, F., Kori, H., and Kageyama, R.:
   "Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information."
   Genes Dev. 31, 524-535 (2017).
8. * Shimojo, H., Isomura, A., Ohtsuka, T., Kori, H., Miyachi, H., and Kageyama, R:
   "Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis."
   Genes Dev. 30, 102-116 (2016).
9. * Imayoshi, I., and Kageyama, R.
   bHLH factors in self-renewal, multipotency, and fate choice of neural progenitor cells.
   Neuron 82, 9-23 (2014).
10. * Imayoshi, I., Isomura, A., Harima, Y., Kawaguchi, K., Kori, H., Miyachi, H., Fujiwara, T.K., Ishidate, F., and Kageyama, R.:
    "Oscillatory control of factors determining multipotency and fate in mouse neural progenitors."
    Science 342, 1203-1208 (2013).