We focus on the causal relationship between perception and neural activity at the single-cell, micro-circuit and network levels
Masanori Murayama, Ph.D.
Team Leader, Haptic Perception and Cognitive Physiology
masanori.murayama [at] riken.jp
Research Overview
Little is known about how neurons integrate feedback and feed forward information for animal behavior. To understand it, we focus on the causal relationship between behavior and neural activity at the single-cell, micro-circuit and network levels. We use multidisciplinary techniques including 2-photon microscopy, fiberoptic imaging, macro-brain imaging, optogenetic techniques and electrophysiological recordings, in awake and anesthetized animals. We are also interested in developing new techniques to discover novel neural activities that can be used for understanding brain functions and animal behavior.
Main Research Fields
Complex Systems
Related Research Fields
Biological Sciences
Keywords
- Consciousness
- Perception
- Mouse
- Neocortex
- Dendrite
Selected Publications
- Miyamoto D, Hirai D, Fung CC, Inutsuka A, Odagawa M, Suzuki T, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, Murayama M.:
"Top-down cortical input during NREM sleep consolidates perceptual memory"
Science, 352(6291):1315-8. (2016).
10.1126/science.aaf0902 - Hirasawa N., Yamada K., and Murayama M.:
"Brief hind paw stimulation is sufficient to induce delayed somatosensory discrimination learning in C57BL/6 mice."
Behavioural Brain Research, Volume 301, 15 March 2016, Pages 102–109
10.1016/j.bbr.2015.12.024 - Suzuki T., and Murayama M.:
"Craniotomy for cortical voltage-sensitive dye imaging in mice"
Bio-protocol, Vol 6, Iss 3, Feb 05, 2016
10.21769/BioProtoc.1722 - Miyamoto D, Murayama M.:
"The fiber-optic imaging and manipulation of neural activity during animal behavior."
Neurosci Res. 2015 Sep 30. pii: S0168-0102(15)00228-X.
10.1016/j.neures.2015.09.004 - Manita S, Suzuki T, Homma C, Matsumoto T, Odagawa M, Yamada K, Ota K, Matsubara C, Inutsuka A, Sato M, Ohkura M, Yamanaka A, Yanagawa Y, NakaiJ, Hayashi Y, Larkum ME, Murayama M.:
"A Top-Down Cortical Circuit for Accurate Sensory Perception."
Neuron. 2015 Jun 3;86(5):1304-16.
10.1016/j.neuron.2015.05.006 - Takekawa T, Ota K, Murayama M, Fukai T.:
"Spike detection from noisy neural data in linear-probe recordings."
Eur J Neurosci. 2014 Jun;39(11):1943-50.
10.1111/ejn.12614 - Lucy M.Palmer, Masanori Murayama, Matthew E. Larkum.:
"Inhibitory Regulation of Dendritic Activity in vivo."
Front Neural Circuits. 2012;6:26, 2012
10.3389/fncir.2012.00026 - Lucy M.Palmer, Jan M.Schulz, Sean C.Murphy, Debora Ledergerber, Masanori Murayama, Matthew E. Larkum.:
"The Cellular Basis of GABAb-Mediated Interhemispheric Inhibition"
Science 24;335(6071):989-93, 2012
10.1126/science.1217276 - Masanori Murayama and Matthew Larkum.:
"Fiber-Optic Calcium Monitoring of Dendritic Activity In Vivo"
Cold Spring Harbor Protocols 1;2012(2):218-25, 2012
10.1101/pdb.prot067835 - H. Lütcke*, M. Murayama*, T. Hahn, D.J. Margolis, S. Astori, S.M.A. Borgloh, W. Göbel, Y. Yang, W. Tang, S.: Kügler, R. Sprengel, T. Nagai, A. Miyawaki, M.E. Larkum, F. Helmchen, M.T. Hasan (* Equal contribution).:
"Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice"
Frontiers in Neural Circuits, 4;9
10.3389/fncir.2010.00009
News & Media
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RIKEN CBS Faculty & Labs: Masanori Murayama, Laboratory for Haptic Perception and Cognitive Physiology
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Fast, cell-resolution, contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas
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The invisible touch
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Mimicking deep sleep brain activity improves memory
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Of mice and NREM: In this brain circuit, memories depend on sleep
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Switching off brain circuit renders mice “out of touch” with environment
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Switching off brain circuit renders mice “out of touch” with environment
Lab Members
Principal investigator
- Masanori Murayama
- Laboratory Head
Core members
- Keisuke Ota
- Research Scientist
- Daichi Hirai
- Research Associate
- Yusuke Atsumi
- Junior Research Associate
- Maya Odagawa
- Technical Staff I
- Chihiro Honma
- Technical Staff I
- Yasuhiro Oisi
- Technical Staff I
- Chie Matsubara
- Technical Staff I
- Rinako Endo
- Technical Staff II
- Mami Suzuki
- Assistant