We focus on the causal relationship between perception and neural activity at the single-cell, micro-circuit and network levels
Masanori Murayama, Ph.D.
Team Director, Haptic Perception and Cognitive Physiology
masanori.murayama@riken.jp
Research Overview
Little is known about how neurons integrate feedback and feed forward information for animal behavior. To understand it, we focus on the causal relationship between behavior and neural activity at the single-cell, micro-circuit and network levels. We use multidisciplinary techniques including 2-photon microscopy, fiberoptic imaging, macro-brain imaging, optogenetic techniques and electrophysiological recordings, in awake and anesthetized animals. We are also interested in developing new techniques to discover novel neural activities that can be used for understanding brain functions and animal behavior.
Main Research Fields
Complex Systems
Related Research Fields
Biological Sciences
Keywords
- Consciousness
- Perception
- Mouse
- Neocortex
- Dendrite
Selected Publications
- Saito Y., Osako Y., Odagawa M., Oisi Y., Matsubara C., Kato S., Kobayashi K., Morita M., Johansen JP., Murayama M.:
“Amygdalo-cortical dialogue underlies memory enhancement by emotional association”
Neuron 113(6) 931-948 e9(2025)
10.1016/j.neuron.2025.01.001 - Ota K., Oisi Y., Suzuki T., Ikeda M., Ito Y., Ito T., Uwamori H., Kobayashi K., Kobayashi M., Odagawa M., Matsubara C., Kuroiwa Y., Horikoshi M., Matsushita J., Hioki H., Ohkura M., Nakai J., Oizumi M., Miyawaki A., Aonishi T., Ode T., Murayama M.:
“Fast, cell-resolution, contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas”
Neuron 109(11) 1810-1824.e9(2021)
10.1016/j.neuron.2021.03.032 - Miyamoto D., Hirai D., Fung CC., Inutsuka A., Odagawa M., Suzuki T., Boehringer R., Adaikkan C., Matsubara C., Matsuki N., Fukai T., McHugh TJ., Yamanaka A., Murayama M.:
"Top-down cortical input during NREM sleep consolidates perceptual memory"
Science, 352(6291):1315-8. (2016).
10.1126/science.aaf0902 - Hirasawa N., Yamada K., and Murayama M.:
"Brief hind paw stimulation is sufficient to induce delayed somatosensory discrimination learning in C57BL/6 mice."
Behavioural Brain Research, Volume 301, 15 March 2016, Pages 102–109
10.1016/j.bbr.2015.12.024 - Miyamoto D., Murayama M.:
"The fiber-optic imaging and manipulation of neural activity during animal behavior."
Neuroscience Research. H 103 1-9 (2016)
10.1016/j.neures.2015.09.004 - Manita S., Suzuki T., Homma C., Matsumoto T., Odagawa M., Yamada K., Ota K., Matsubara C., Inutsuka A., Sato M., Ohkura M., Yamanaka A., Yanagawa Y., Nakai J., Hayashi Y., Larkum M.E., Murayama M.:
"A Top-Down Cortical Circuit for Accurate Sensory Perception."
Neuron 86(5) 1304-1316 (2015)
10.1016/j.neuron.2015.05.006 - Palmer LM., Murayama M., Larkum ME.:
"Inhibitory Regulation of Dendritic Activity in vivo."
Front Neural Circuits. 6:26, (2012)
10.3389/fncir.2012.00026 - Palmer LM., Schulz JM., Murphy SC., Ledergerber D., Murayama M., *Larkum ME.:
"The Cellular Basis of GABAb-Mediated Interhemispheric Inhibition"
Science 24;335(6071):989-93, (2012)
10.1126/science.1217276 -
Lütcke H.*, Murayama M.*, Hahn T., Margolis DJ., Astori S., Zum Alten Borgloh SM., Göbel W., Yang Y., Tang W., Kügler S., Sprengel R., Nagai T., Miyawaki A., Larkum ME., Helmchen F., Hasan MT (* Equal contribution).:
"Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice"
Frontiers in Neural Circuits, 4;9 (2010)
10.3389/fncir.2010.00009 - Murayama M., Pérez-Garci E., Nevian T., Bock T., Senn W., Larkum ME.:
“Dendritic encoding of sensory stimuli controlled by deep cortical interneurons”
Nature 457(7233) 1137-1141 (2009)
10.1038/nature07663
News & Media
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Positive emotions plus deep sleep equals longer-lasting perceptual memories
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RIKEN CBS Faculty & Labs: Masanori Murayama, Laboratory for Haptic Perception and Cognitive Physiology
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Fast, cell-resolution, contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas
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The invisible touch
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Mimicking deep sleep brain activity improves memory
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Of mice and NREM: In this brain circuit, memories depend on sleep
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Switching off brain circuit renders mice “out of touch” with environment
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Switching off brain circuit renders mice “out of touch” with environment
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Lab Members
Principal investigator
- Masanori Murayama
- Team Director
Core members
- Yasuhiro Oisi
- Research Scientist
- Hiroyuki Uwamori
- Research Scientist
- Ikumi Oomoto
- Special Postdoctoral Researcher
- Kotaro Ishizu
- Special Postdoctoral Researcher
- Yusuke Atsumi
- Research Associate
- Tomoki Osuka
- Research Associate
- Toshiki Tani
- Technical Scientist
- Maya Odagawa
- Technical Staff I
- Chihiro Honma
- Technical Staff I
- Tomomitsu Karaki
- Technical Staff I
- Yuri Shinomoto
- Technical Staff I
- Chie Matsubara
- Technical Staff I
- Midori Kobayashi
- Technical Staff II
- Mami Suzuki
- Assistant