We study how aversive experiences trigger alterations in brain circuits and neural coding resulting in emotional memory formation.
Joshua Johansen, Ph.D.
Team Director, Neural Circuitry of Learning and Memory
joshua.johansen@riken.jp
- Research Overview
- Selected Publications
- News & Media
- Lab Members
- Curriculum Vitae
- Laboratory Website
- Seeking a Research Associate (W24230)
- Part-time Staff Position (W24267)
Research Overview
Innately aversive experiences produce emotional states in the brain which coordinate bodily reactions and trigger memory formation. However, more complex emotions occur through an evaluation of our circumstances in the context of past experiences and current internal physiological conditions.
The Johansen lab studies the neural circuits and cell coding mechanisms which translate aversive experiences into simple and complex emotional states in the brain to guide behavior and produce memories.
Our work will provide a mechanistic understanding of emotions, learning & memory and other aspects of human experience, ultimately leading to better treatment options for anxiety and trauma related psychiatric conditions.
Keywords
- neuromodulation
- neuronal coding
- behavior
- Learning and Memory
- Emotion
Selected Publications
- Gu X, Johansen JP
"Prefrontal encoding of an internal model for emotional inference"
Nature, (2025)
10.1038/s41586-025-09001-2 - Watanabe M, Uematsu A, Johansen JP
"Bidirectional emotional regulation through prefrontal innervation of the locus coeruleus"
Molecular Psychiatry, (2025)
10.1038/s41380-025-02944-y - Sulkes Cuevas J, Watanabe M, Uematsu A, Johansen JP
"Whole-brain afferent input mapping to functionally distinct brainstem noradrenaline cell types"
Neuroscience Research, Apr. 14, S0168-0102(23)00074-3 (2023)
10.1016/j.neures.2023.04.004 - Ormond J, Serka AS, Johansen JP
"Enhanced reactivation of remapping place cells during aversive learning"
Journal of Neuroscience, Jan. 3, JN-RM-1450-22 (2023)
10.1523/JNEUROSCI.1450-22.2022 - Yeh LF, Ozawa T, Johansen JP
"Functional organization of the midbrain periaqueductal gray for regulating aversive memory formation"
Molecular Brain, 14, 136 (2021)
10.1186/s13041-021-00844-0 - Poe GR, Foote S, Eschenko O, Johansen JP, Bouret S, Aston-Jones G, Harley CW, Manahan-Vaughan D, Weinshenker D, Valentino R, Berridge C, Chandler DJ, Waterhouse B, Sara SJ
"Locus coeruleus: a new look at the blue spot"
Nature Reviews Neuroscience, 21, 644-659 (2020)
10.1038/s41583-020-0360-9 - Likhtik E, Johansen JP
"Neuromodulation in Circuits of Aversive Emotional Learning"
Nature Neuroscience, Nov:22(11):1946 (2019)
https://pubmed.ncbi.nlm.nih.gov/31551602/ - Uematsu A, Tan BZ, Ycu EA, Sulkes-Cuevas J, Koivumaa J, Junyent F, Kremer EJ, Witten IB, Deisseroth K, Johansen JP
"Modular organization of the brainstem noradrenaline system coordinates opposing learning states"
Nature Neuroscience, 20(11):1602-1611 (2017)
https://www.nature.com/articles/nn.4642 - Ozawa T, Ycu EA, Kumar A, Yeh L-F, Ahmed T, Koivumaa J, Johansen JP
"A feedback neural circuit for calibrating aversive memory strength"
Nature Neuroscience, 20(1):90-97 (2017)
https://www.ncbi.nlm.nih.gov/pubmed/27842071 - Madarasz TJ, Diaz-Mataix L Akhand O, Ycu EA, LeDoux JE, Johansen JP
"Evaluation of ambiguous associations in the amygdala by learning the structure of the environment"
Nature Neuroscience, 19:965-972 (2016)
https://www.ncbi.nlm.nih.gov/pubmed/27214568
News & Media
-
-
-
How the brain allows us to infer emotions
-
-
-
-
NEURO SQUARE "Constructing emotion in neural circuits" by Joshua Johansen
-
-
-
-
A researcher’s journey: from surfing to studying pain
-
-
-
-
Freedom from fear
-
-
-
-
Freedom from fear: dopamine’s role in unlearning fearful associations
-
-
-
-
Learning and unlearning to fear: The two faces of noradrenaline
-
-
-
-
The power of expectation can restrain hyper-emotional memories in the brain
-
-
-
-
The uncertain brain: untangling ambiguity in neural circuits
-
-
-
-
Shedding new light on the formation of emotional fear memories
-
Lab Members
Principal investigator
- Joshua Johansen
- Team Director
Core members
- Xiaowei Gu
- Research Scientist
- Nur Zeynep Gungor
- Research Scientist
- Tomoya Ohnuki
- Special Postdoctoral Researcher
- Mehdi Julien Sicre
- Special Postdoctoral Researcher
- Yusuke Kasuga
- Research Associate
- Kun-Lin Hsieh
- Research Associate
- Yuri Ishizu
- Technical Staff I
- Reiko Yoshida
- Technical Staff I
- Yuki Goya
- Technical Staff I