Understanding cellular mechanisms that control nervous system formation and repair

Hiroyuki Kamiguchi

Hiroyuki Kamiguchi, M.D., Ph.D.

Team Leader, Neural Cell Dynamics
hiroyuki.kamiguchi [at] riken.jp

Research Overview

The development of functional neuronal networks relies on the spatial accuracy of axon extension. Each extending axon is tipped by a growth cone that can interpret extracellular "guidance cues" and navigate the axon along the correct path. After neuronal networks have been developed, injury to the adult central nervous system induces the formation of barriers to regenerating axons. It is well known that growth cones use similar mechanisms for their navigation during development and regeneration. Our aim is to investigate growth cone navigation with particular emphasis on the roles of guidance cues, intracellular signals, cytoskeleton, adhesion machinery and membrane dynamics. These revelations will help elucidate the fundamental principles of axon tract formation and establish the molecular and cellular biological basis for axon tract repair.

Main Research Field

Related Research Fields


Selected Publications

  • Akiyama H, Fukuda T, Tojima T, Nikolaev VO, and Kamiguchi H:
    "Cyclic nucleotide control of microtubule dynamics for axon guidance."
    The Journal of Neuroscience, 36(20), 5636-5649 (2016)
  • Wada F, Nakata A, Tatsu Y, Ooashi N, Fukuda T, Nabetani T, and Kamiguchi H:
    "Myosin Va and endoplasmic reticulum calcium channel complex regulates membrane export during axon guidance."
    Cell Reports, 15(6), 1329-1344 (2016)
  • Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P, Inoue A, Nabetani T, Murayama A, Ohta K, Ito Y, Aoki J, Hirabayashi Y, and Kamiguchi H:
    "Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord."
    Science, 349(6251), 974-977 (2015)
  • Tojima T, Itofusa R, and Kamiguchi H:
    "Steering Neuronal Growth Cones by Shifting the Imbalance between Exocytosis and Endocytosis."
    The Journal of Neuroscience, 34(21), 7165-78 (2014)
  • Tojima T, Hines JH, Henley JR, and Kamiguchi H:
    "Second messengers and membrane trafficking direct and organize growth cone steering."
    Nature Reviews Neuroscience 12(4), 191-203 (2011)
  • Akiyama H, and Kamiguchi H:
    "Phosphatidylinositol 3-kinase facilitates microtubule-dependent membrane transport for neuronal growth cone guidance."
    The Journal of Biological Chemistry 285(53), 41740-41748 (2010)
  • Tojima T, Itofusa R, and Kamiguchi H:
    "Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance."
    Neuron 66(3), 370-377 (2010)
  • Tamada A, Kawase S, Murakami F, and Kamiguchi H:
    "Autonomous right-screw rotation of growth cone filopodia drives neurite turning."
    The Journal of Cell Biology 188(3), 429-441(2010)
  • Akiyama H, Matsu-ura T, Mikoshiba K, and Kamiguchi H:
    "Control of neuronal growth cone navigation by asymmetric inositol 1,4,5-trisphosphate signals."
    Science Signaling 2(79), ra34 (2009)
  • Tojima T, Akiyama H, Itofusa R, Li Y, Katayama H, Miyawaki A, and Kamiguchi H:
    "Attractive axon guidance involves asymmetric membrane transport and exocytosis in the growth cone."
    Nature Neuroscience 10(1), 58-66 (2007)

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