Masanori Matsuzaki

Masanori Matsuzaki, Ph.D.

Team Leader, Brain Functional Dynamics Collaboration Laboratory
masanori.matsuzaki [at]

Research Overview

We develop cognitive tasks for the common marmoset. We use fluorescent imaging methods to measure the dynamics of the neuronal activity in the marmoset cerebral cortex during the task performance. We also use optogenetics and chemogenetics to manipulate the neuronal activity during the task performance to reveal the causal relationship between the task-relevant activity and behaviors.

Main Research Fields

Biological Sciences

Related Research Fields

Informatics / Biological Sciences / Biology / Medicine, Dentistry & Pharmacy / Basic/Social brain science / Neurophysiology/General neuroscience


Selected Publications

  1. Obara K., Ebina T., Terada S., Uka T., Komatsu Y., Takaji M., Watakabe A., Kobayashi K., Masamizu Y., Mizukami H., Yamamori T., Kasai K., Matsuzaki M.:
    “Change detection in the primate auditory cortex through feedback of prediction error signals.”
    Nature Communications 14, 6981, 2023.
    doi: 10.1038/s41467-023-42553-3.
  2. Kondo M., Matsuzaki M.:
    “Neuronal representations of reward-predicting cues and outcome history with movement in the frontal cortex.”
    Cell Reports 34, 108704, 2021.
    doi: 10.1016/j.celrep.2021.108704.
  3. Matsuzaki M., Ebina T.
    "Common marmoset as a model primate for study of the motor control system."
    Current Opinion in Neurobiology 64, 103-110, 2020.
  4. Ebina T., Obara K., Watakabe A., Masamizu Y., Terada S., Matoba R., Takaji M., Hatanaka A., Nambu A., Mizukami H., Yamamori T., Matsuzaki M.
    "Arm movements induced by non-invasive optogenetic stimulation of the motor cortex in the common marmoset."
    Proc Natl Acad Sci USA 116, 22844-22850, 2019.
  5. *Terada S., Kobayashi K., Ohkura M., Nakai J., Matsuzaki M.
    "Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space."
    Nature Communications 9, 3550, 2018.
  6. *Tanaka Y.H., Tanaka Y.R., Kondo M., Terada S., Kawaguchi Y., Matsuzaki M.
    "Thalamocortical axonal activity in motor cortex exhibits layer-specific dynamics during motor learning."
    Neuron 100, 244-258, 2018.
  7. *Ebina T., Masamizu Y., Tanaka Y.R., Watakabe A., Hirakawa R., Hirayama Y., Hira R., Terada S., Koketsu D., Hikosaka K., Mizukami H., Nambu A., Sasaki E., Yamamori T., Matsuzaki M.
    "Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks."
    Nature Communications 9, 1879, 2018.
  8. *Sadakane O., Masamizu Y., Watakabe A., Terada S., Ohtsuka M., Takaji M., Mizukami H., Ozawa K., Kawasaki H., Matsuzaki M., Yamamori T.
    "Long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human primates."
    Cell Reports 13, 1989-1999, 2015.
  9. *Hira R., Ohkubo F., Masamizu Y., Ohkura M., Nakai J., Okada T., Matsuzaki M.
    "Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning."
    Nature Communications 5, 5551, 2014.
  10. *Masamizu Y., Tanaka Y.R., Tanaka Y.H., Hira R., Ohkubo F., Kitamura K., Isomura Y., Okada T., Matsuzaki M.
    "Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task."
    Nature Neuroscience 17, 987-994, 2014.

Lab Members

Principal investigator

Masanori Matsuzaki
Team Leader

Core members

Rieko Setsuie
Research Scientist
Cristina Risueno Segovia
Special Postdoctoral Researcher
Binglun Li
Special Postdoctoral Researcher