Masanori MatsuzakiMasanori Matsuzaki

Masanori Matsuzaki, Ph.D.

Team Leader, Brain Functional Dynamics Collaboration Laboratory
masanori.matsuzaki [at]

Research Overview

We develop cognitive tasks for the common marmoset. We use fluorescent imaging methods to measure the dynamics of the neuronal activity in the marmoset cerebral cortex during the task performance. We also use optogenetics and chemogenetics to manipulate the neuronal activity during the task performance to reveal the causal relationship between the task-relevant activity and behaviors.

Main Research Field

Biological Sciences

Related Research Fields

Informatics / Biological Sciences / Biology / Medicine, dentistry, and pharmacy
Basic/Social brain science / Neurophysiology/General neuroscience


Selected Publications

  • *Terada S., Kobayashi K., Ohkura M., Nakai J., Matsuzaki M.:
    "Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space."
    Nature Communications 9, 3550, 2018.
  • *Tanaka Y.H., Tanaka Y.R., Kondo M., Terada S., Kawaguchi Y., Matsuzaki M.:
    "Thalamocortical axonal activity in motor cortex exhibits layer-specific dynamics during motor learning."
    Neuron 100, 244-258, 2018.
  • *Yoshida E., Terada S., Tanaka Y.H., Kobayashi K., Ohkura M., Nakai J., Matsuzaki M.:
    "Wide-field calcium imaging of mouse thalamocortical synapses with an 8 K ultra-high-definition camera."
    Scientific Reports 8, 8324, 2018.
  • *Ebina T., Masamizu Y., Tanaka Y.R., Watakabe A., Hirakawa R., Hirayama Y., Hira R., Terada S., Koketsu D., Hikosaka K., Mizukami H., Nambu A., Sasaki E., Yamamori T., Matsuzaki M.:
    "Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks."
    Nature Communications 9, 1879, 2018.
  • *Kondo M., Kobayashi K., Ohkura M., Nakai J., Matsuzaki M.:
    "Two-photon calcium imaging of the medial prefrontal cortex and hippocampus without cortical invasion."
    eLife 6, e26839, 2017.
  • *Sadakane O., Masamizu Y., Watakabe A., Terada S., Ohtsuka M., Takaji M., Mizukami H., Ozawa K., Kawasaki H., Matsuzaki M., Yamamori T.:
    "Long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human primates."
    Cell Reports 13, 1989-1999, 2015.
  • *Hira R., Terada S., Kondo M., Matsuzaki M.:
    "Distinct functional modules for discrete and rhythmic forelimb movements in the mouse motor cortex."
    Journal of Neuroscience 35, 13311-13322, 2015.
  • *Hira R., Ohkubo F., Masamizu Y., Ohkura M., Nakai J., Okada T., Matsuzaki M.:
    "Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning."
    Nature Communications 5, 5551, 2014.
  • *Masamizu Y., Tanaka Y.R., Tanaka Y.H., Hira R., Ohkubo F., Kitamura K., Isomura Y., Okada T., Matsuzaki M.:
    "Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task."
    Nature Neuroscience 17, 987-994, 2014.
  • *Hira R., Ohkubo F., Ozawa K., Isomura Y., Kitamura K., Kano M., Kasai H., Matsuzaki M.:
    "Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement."
    Journal of Neuroscience 33, 1377-1390, 2013.