Masanori Matsuzaki, Ph.D.

Research Overview

We develop cognitive tasks for the common marmoset. We use fluorescent imaging methods to measure the dynamics of the neuronal activity in the marmoset cerebral cortex during the task performance. We also use optogenetics and chemogenetics to manipulate the neuronal activity during the task performance to reveal the causal relationship between the task-relevant activity and behaviors.

Main Research Fields

Biological Sciences

Related Research Fields

Informatics / Biological Sciences / Biology / Medicine, Dentistry & Pharmacy / Basic/Social brain science / Neurophysiology/General neuroscience

Keywords

• Two-photon imaging
• Marmoset
• Prefrontal cortex
• Neuron

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

1. Nomura S., Terada S., Ebina T., Uemura M., Masamizu Y., Ohki K., Matsuzaki M.
   "ARViS: A bleed-free multi-site automated inejction robot for accurate, fast, and dense delivery of virus to mouse and marmoset cerebral cortex."
   Nature Communications 15, 7633, 2024.
   doi: 10.1038/s41467-024-51986-3
2. Ebina T., Sasagawa T., Hong D. Setsuie R., Obara K., Masamizu Y., Kondo M., Terada S., Ozawa K., Uemura M., Takaji M., Watakabe A., Yamamori T., Ohki K., Murayama M., Matsuzaki M.
   "Dynamics of directional motor tuning in the primate premotor and primary motor cortices during sensorimotor learning."
   Nature Communications 15, 7127, 2024.
   doi: 10.1038/s41467-024-51425-3
3. Obara K., Ebina T., Terada S., Uka T., Komatsu Y., Takaji M., Watakabe A., Kobayashi K., Masamizu Y., Mizukami H., Yamamori T., Kasai K., Matsuzaki M.:
   “Change detection in the primate auditory cortex through feedback of prediction error signals.”
   Nature Communications 14, 6981, 2023.
   doi: 10.1038/s41467-023-42553-3.
4. Matsuzaki M., Ebina T.
   "Common marmoset as a model primate for study of the motor control system."
   Current Opinion in Neurobiology 64, 103-110, 2020.
   10.1016/j.conb.2020.02.013.
5. * Ebina T., Obara K., Watakabe A., Masamizu Y., Terada S., Matoba R., Takaji M., Hatanaka A., Nambu A., Mizukami H., Yamamori T., Matsuzaki M.
   "Arm movements induced by non-invasive optogenetic stimulation of the motor cortex in the common marmoset."
   Proc Natl Acad Sci USA 116, 22844-22850, 2019.
   10.1073/pnas.1903445116.
6. *Terada S., Kobayashi K., Ohkura M., Nakai J., Matsuzaki M.
   "Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space."
   Nature Communications 9, 3550, 2018.
   10.1038/s41467-018-06058-8.
7. *Tanaka Y.H., Tanaka Y.R., Kondo M., Terada S., Kawaguchi Y., Matsuzaki M.
   "Thalamocortical axonal activity in motor cortex exhibits layer-specific dynamics during motor learning."
   Neuron 100, 244-258, 2018.
   10.1016/j.neuron.2018.08.016.
8. *Ebina T., Masamizu Y., Tanaka Y.R., Watakabe A., Hirakawa R., Hirayama Y., Hira R., Terada S., Koketsu D., Hikosaka K., Mizukami H., Nambu A., Sasaki E., Yamamori T., Matsuzaki M.
   "Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks."
   Nature Communications 9, 1879, 2018.
   10.1038/s41467-018-04286-6.
9. *Sadakane O., Masamizu Y., Watakabe A., Terada S., Ohtsuka M., Takaji M., Mizukami H., Ozawa K., Kawasaki H., Matsuzaki M., Yamamori T.
   "Long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human primates."
   Cell Reports 13, 1989-1999, 2015.
   10.1016/j.celrep.2015.10.050.
10. *Masamizu Y., Tanaka Y.R., Tanaka Y.H., Hira R., Ohkubo F., Kitamura K., Isomura Y., Okada T., Matsuzaki M.
    "Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task."
    Nature Neuroscience 17, 987-994, 2014.
    10.1038/nn.3739.