Atsushi Takata, M.D., Ph.D.

Research Overview

Neuropsychiatric disorders such as schizophrenia, mood disorders, and autism spectrum disorders are common disorders severely affecting the quality and quantity of the lives of the patients and their families. Despite many studies, their fundamental biological basis is still unknown, and even today, "psychopathology" depends not on the pathological change of the responsible organ, but on the observation and description of symptoms and their interpretation (and generally it is more pragmatic). On the other hand, due to the recent advances in molecular biology, molecular genetics, and computational science, now it has become possible to search the "pathology" of neuropsychiatric disorders at the resolution of molecules or single-base DNA sequences. In our laboratory, we take full advantage of the cutting-edge technologies to elucidate the molecular pathology of neuropsychiatric disorders, aiming to redefine their "pathology" and develop new diagnostic, therapeutic, and/or preventive procedures designed based on the biological understanding of the disorders.

Main Research Fields

Medicine, Dentistry & Pharmacy

Related Research Fields

Biological Sciences / Neuropsychiatry / Human genetics / Genome Medicine

Keywords

• Psychiatric disorder
• Genomics
• Epigenetics
• Statistical genetics
• Animal models

Selected Publications

1. Nakamura T., Yoshihara T., Tanegashima C., Kadota M., Kobayashi Y., Honda K., Ishiwata M., Ueda J., Hara T., Nakanishi M., Takumi T., Itohara S., Kuraku S., Asano M., Kasahara T., Nakajima K., Tsuboi T., Takata A., Kato T.:
   "Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor."
   Molecular Psychiatry. (2024)
2. Nakamura T., Ueda J., Mizuno S., Honda K., Kazuno A.-A., Yamamoto H., Hara T., Takata A.:
   "Topologically associating domains define the impact of de novo promoter variants on autism spectrum disorder risk."
   Cell Genomics. (2024)
3. Nishioka M., Takayama J., Sakai N., Kazuno A.-A., Ishiwata M., Ueda J., Hayama T., Fujii K., Someya T., Kuriyama S., Tamiya G., Takata A., Kato T.:
   "Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in bipolar disorder."
   Molecular Psychiatry. (2023)
4. Nakamura T., Takata A.:
   "The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research."
   Molecular Psychiatry. (2023)
5. Nishioka M, Kazuno A-a, Nakamura T, Sakai N, Hayama T, Fujii K, Matsuo K, Komori A, Ishiwata M, Watanabe Y, Oka T, Matoba N, Kataoka M, Alkanaq AN, Hamanaka K, Tsuboi T, Sengoku T, Ogata K, Iwata N, Ikeda M, Matsumoto N, Kato T, Takata A.:
   "Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder"
   Nat Commun. (2021)
6. Takata A, Hamanaka K, Matsumoto N.:
   "Refinement of the clinical variant interpretation framework by statistical evidence and machine learning"
   Med 2, 611-632.e9. (2021)
7. Takata A, Nakashima M, Saitsu H, Mizuguchi T, Mitsuhashi S, Takahashi Y, Okamoto N, Osaka H, Nakamura K, Tohyama J, Haginoya K, Takeshita S, Kuki I, Okanishi T, Goto T, Sasaki M, Sakai Y, Miyake N, Miyatake S, Tsuchida N, Iwama K, Minase G, Sekiguchi F, Fujita A, Imagawa E, Koshimizu E, Uchiyama Y, Hamanaka K, Ohba C, Itai T, Aoi H, Saida K, Sakaguchi T, Den K, Takahashi R, Ikeda H, Yamaguchi T, Tsukamoto K, Yoshitomi S, Oboshi T, Imai K, Kimizu T, Kobayashi Y, Kubota M, Kashii H, Baba S, Iai M, Kira R, Hara M, Ohta M, Miyata Y, Miyata R, Takanashi J, Matsui J, Yokochi K, Shimono M, Amamoto M, Takayama R, Hirabayashi S, Aiba K, Matsumoto H, Nabatame S, Shiihara T, Kato M, Matsumoto N.:
   "Comprehensive analysis of coding variants highlights genetic complexity in developmental and epileptic encephalopathy"
   Nat. Commun. 10, 2506. (2019)
8. * Takata A, Matsumoto N, Kato T.:
   "Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci"
   Nat. Commun. 8, 14519. (2017)
9. * Takata A, Ionita-Laza I, Gogos JA, Xu B, Karayiorgou M.:
   "De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia"
   Neuron 89, 940-947. (2016)
10. Takata A, Xu B, Ionita-Laza I, Roos JL, Gogos JA, Karayiorgou M.:
    "Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene"
    Neuron 82, 773-780. (2014)