Diversity is vital. Our brain is the ultimate complex society; it works through interactions between many different neuron types, each of which has a special job. After a neuron is born, how does it grow up to be different?

Adrian Moore

Adrian Moore, Ph.D.

Team Leader, Neurodiversity
adrian.moore [at] riken.jp

Research Overview

The long term aim of our lab is to understand the regulatory control systems that guide neuron differentiation and morphogenesis. With this plan, we aim to reveal fundamental molecular mechanisms that create form and function in the nervous system. Our research will also contribute to explaining the dysregulated mechanisms that cause neurodevelopmental disorders, and it can suggest ways we can reawaken the neuron differentiation program for neuronal repair. Please see our lab website to find out more about our research, and lab life

Main Research Fields

Biological Sciences

Related Research Fields

Interdisciplinary Science & Engineering / Biology / Medicine, Dentistry & Pharmacy / Neuroscience-general-related / Cell biology-related / Developmental biology-related

Keywords

Selected Publications

  1. Suzuki T., Tatsukawa T., Sudo G., Delandre C., Pai YJ., Miyamoto H., Raveau M., Shimohata A., Ohmori I., Hamano S., Haginoya K., Uematsu M., Takahashi Y., Morimoto M., Fujimoto S., Osaka H., Oguni H., Osawa M., Ishii A., Hirose S., Kaneko S., Inoue Y., Moore AW., Yamakawa K.
    CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainite
    Scientific Reports 12, e6505. (2022).
  2. Pai YJ., Moore AW.
    Transcription factor encoding of neuron subtype: strategies that specify arbor pattern
    Curr. Opin. Neurobiol. 69, pp149-158. (2021).
  3. Yoong LF., Lim HK., Tran H., Lackner S., Zheng Z., Hong P., Moore AW.
    Atypical myosin tunes dendrite arbor subdivision
    Neuron 106, pp452-467. (2020).
  4. Rives-Quinto N., Komori N., Ostgaard CM., Janssens DH., Kondo S., Dai Q., Moore AW., Lee CY.
    Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes
    Elife 9, e56187. (2020).
  5. Liang X., Kokes M., Fetter RD., Sallee MD., Moore AW., Feldman JL., Shen K.
    Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites
    Elife 9, e56547. (2020).
  6. Wilkes OR., Moore AW.
    Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity
    Front. Cell. Neurosci. 14, e398. (2020).
  7. Urun FR., Moore AW.
    Visualizing Cell Cycle Phase Organization and Control During Neural Lineage Elaboration
    Cells 9, e2112. (2020).
  8. Chen YC., Auer-Grumbach M., Matsukawa S., Zitzelsberger M., Themistocleous AC., Strom TM., Samara C., Moore AW., Cho LT., Young GT., Weiss C., Schabhüttl M., Stucka R., Schmid AB., Parman Y., Graul-Neumann L., Heinritz W., Passarge E., Watson RM., Hertz JM., Moog U., Baumgartner M., Valente EM., Pereira D., Restrepo CM., Katona I., Dusl M., Stendel C., Wieland T., Stafford F., Reimann F., von Au K., Finke C., Willems PJ., Nahorski MS., Shaikh SS., Carvalho OP., Nicholas AK., Karbani G., McAleer MA., Cilio MR., McHugh JC., Murphy SM., Irvine AD., Jensen UB., Windhager R., Weis J., Bergmann C., Rautenstrauss B., Baets J., De Jonghe P., Reilly MM., Kropatsch R., Kurth I., Chrast R., Michiue T., Bennett DL., Woods CG., Senderek J.
    Transcriptional regulator PRDM12 is essential for human pain perception
    Nat. Genet. 7, pp803-8. (2015)
  9. Yalgin C., Ebrahimi S., Delandre C., Yoong LF., Akimoto S., Tran H., Amikura R., Spokony R., Torben-Nielsen B., White KP., Moore AW.
    Centrosomin represses dendrite branching by orienting microtubule nucleation
    Nat. Neurosci. 18, pp1437-45. (2015).
  10. Endo K., Karim MR., Taniguchi H., Krejci A., Kinameri E., Siebert M., Ito K., Bray S., Moore AW.
    Chromatin modification of Notch targets in olfactory receptor neuron diversification
    Nat. Neurosci. 15, pp224-33. (2012).

Lab Members

Principal investigator

Adrian Walton Moore
Laboratory Head

Core members

Fatma Rabia Urun
Postdoctoral Researcher
Yong You Jason Tann
Postdoctoral Researcher
Cecilia Benazzato
Postdoctoral Researcher
Fangke Xu
Special Postdoctoral Researcher
Minami Kimura
Technical Staff I