We aim to elucidate synaptic interaction mechanisms that regulate neural circuit activity underlying particular behaviors
Yukiko Goda, Ph.D.
Team Leader, Synaptic Plasticity and Connectivity
yukiko.goda [at] riken.jp
Synapses are the nodes of information transmission in the brain. The dynamic changes in the efficacy of synaptic transmission or synaptic strength, play crucial roles in a variety of cognitive functions from perception, emotion, computation, to learning and memory. Our research seeks to understand how synapses acquire a particular strength and how the strength of individual synapses is dynamically modified in relationship to other synapses of the neural network. We study how these mechanisms of synaptic strength regulation control neural circuit properties underlying particular types of behavior.
Main Research Field
- Park YK, Goda Y.:
"Integrins in synapse regulation"
Nat Rev Neurosci 17, 745-756 (2016)
- Letellier M, Park YK, Chater TE, Chipman PH, Gautam SG, Oshima-Takago T, Goda Y.:
"Astrocytes regulate heterogeneity of presynaptic strengths in hippocampal networks"
Proc Natl Acad Sci USA 113, E2685-2694 (2016)
- Shinoe T, Goda Y.:
"Tuning synapses by proteolytic remodeling of the adhesive surface"
Curr Op Neurobiol 35, 148-155 (2015)
- Vitureira N, Goda Y.:
"The interplay between Hebbian and homeostatic synaptic plasticity"
J Cell Biol 203, 175-186 (2013)
- * McGeachie AB, Skrzypiec AE, Cingolani LA, Letellier M, Pawlak R, and Goda Y.:
"Beta3 integrin is dispensable for conditioned fear and Hebbian forms of synaptic plasticity in the hippocampus"
Eur J Neurosci 36, 2461-2469 (2012)
- * Pozo K, Cingolani LA, Bassani S, Laurent F, Passafaro M, Goda Y.:
"Beta3 integrin interacts directly with GluA2 AMPA receptor subunit and regulates AMPA receptor expression in hippocampal neurons"
Proc Natl Acad Sci USA 109, 1323-1328 (2012)
- * Vitureira N, Letellier M, White IJ, Goda Y.:
"Differential control of presynaptic efficacy by postsynaptic N-cadherin and beta-catenin"
Nat Neurosci 15, 81-89 (2011)
- * Staras K, Branco T, Burden JJ, Pozo K, Darcy K, Marra V, Ratnayaka A, Goda Y.:
"A Vesicle superpool spanning multiple presynaptic terminals in hippocampal neurons"
Neuron 66, 36-44 (2010)
- * Branco T, Staras K, Darcy KJ, Goda Y.:
"Local dendritic activity sets release probability at hippocampal synapses"
Neuron 58, 749-762 (2008)
- * Cingolani LA, Thalhammer A, Yu LM, Catalano M, Ramos T, Colicos MA, Goda Y.:
"Activity-dependent regulation of synaptic AMPA receptor composition and abundance by β3 integrins"
Neuron 58, 749-762 (2008)
News & Media
Apr. 26, 2016（Press Release）
Nov. 12, 2013（Article）