Kayoko Esaki

Kayoko Esaki, Ph.D.

CDP-YCI: CDP: Career Development Program - Young Chief Investigator
kayoko.esaki [at] riken.jp

Research Overview

The brain is known as a lipid-rich tissue in our body. Lipids in the brain play an important role in brain development and function by participating in the formation of myelin sheaths that help nerve cells communicate and in the elongation of nerve cell processes. Recently, there has been a great deal of research on how abnormalities in the cranial nerves are involved in the pathophysiology of psychiatric disorders. Among them, I have been researching the involvement of lipid metabolism in the pathophysiology of psychiatric disorders and how lipid metabolism affects cranial nerve function.

Main Research Field

Related Research Fields

Keywords

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  1. Shimamoto-Mitsuyama C, Nakaya A, Esaki K, Balan S, Iwayama Y, Ohnishi T, Maekawa M, Toyota T, Dean B, Yoshikawa, T.
    "Lipid Pathology of the Corpus Callosum in Schizophrenia and the Potential Role of Abnormal Gene Regulatory Networks with Reduced Microglial Marker Expression"
    Cereb. Cortex, 31(1), 448-462, 2021.
  2. Esaki K, Balan S, Iwayama Y, Shimamoto-Mitsuyama C, Hirabayashi Y, Dean B, Yoshikawa T.
    "Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia"
    Schizophr. Bull., 46, pp. 1172-1181, 2020.
  3. Kaplan E, Zubedat S, Rechnitz O, Sason H, Radzishevsky I, Sajrawi C, Bodner O, Konno K, Esaki K, Derdikman D, Yoshikawa T, Watanabe M, Billard J-M, Avital A, Wolosker H.
    "The ASCT1 (Slc1a4) Transporter is a Physiologic Regulator of Brain D-Serine and Neurodevelopment."
    Proc. Natl. Acad. Sci. USA, 115, pp. 9628-9633, 2018.
  4. Sayano T, KawanoY, Kusada W, Arimoto Y, Esaki K, Hamano M, Udono M, Katakura Y, Ogawa T, Kato H, Hirabayashi Y, Furuya S.
    "Adaptive response to L-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts"
    FEBS Open Bio, 6, pp. 303-316, 2016.
  5. Esaki K, Sayano T, Sonoda C, Akagi T, Suzuki T, Ogawa T, Okamoto M, Yoshikawa T, Hirabayashi Y, and Furuya S.
    "L-Serine deficiency elicits intracellular accumulation of cytotoxic deoxy-sphingolipids and lipid body formation."
    J. Biol. Chem, 290, pp. 14595-14609, 2015.
  6. * Esaki K, Ohmori T, Maebuchi M, Nakamori T, Ohshima T, Furuya S.
    "Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY."
    Biosci. Biotech. Biochem, 77, pp. 847-849, 2013.
  7. Sayano T, Kawakami Y, Kusada W, Suzuki T, Kawano Y, Watanabe A, Takashima K, Arimoto Y, Esaki K, Wada A, Yoshizawa F, Watanabe M, Okamoto M, Hirabayashi Y, Furuya S.
    "L-Serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the developing central nervous system."
    FEBS J., 280, pp. 1502-17, 2013.
  8. Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura H. K, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton N. M, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
    "Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia."
    Neuropsychopharmacology, 38, pp. 1409-25, 2013.
  9. * Esaki K**, Kokido T**, Omori T, Tsukino M, Oshima T, Furuya S. **equal contribution.
    "Soy peptide ingestion increases neuroactive amino acids in the brain of wild-type and genetically engineered serine-deficient mice."
    J. Nutr. Food Sci, 1, pp. 109, 2011.
  10. Yang J.H, Wada A, Yoshida K, Miyoshi Y, Sayano T, Esaki K, Kinoshita O.M, Tomonaga S, Azuma N, Watanabe M, Hamase K, Zaitsu K, Machida T, Messing A, Itohara S, Hirabayashi Y, Furuya S.
    "Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an NMDA receptor co-agonist, in adult brain."
    J. Biol. Chem, 285, pp. 41380-41390, 2010.