Our goal is to understand the neural basis of sensory perception and sensory-based decision making through the integration of experimental and theoretical approaches

Andrea BenucciAndrea Benucci

Andrea Benucci, Ph.D.

Team Leader, Laboratory for Neural Circuits and Behavior
andrea.benucci [at] riken.jp

Research Overview

Our laboratory studies the neural basis of sensory processing with a major focus on vision. We are particularly interested in understanding the computational rules used by populations of neurons in the visual cortex to process visual information: how does the coordinated activity of groups of neurons, “talking” among each other via action potentials, produce a visual percept? What are the relevant spatial and temporal scales used to process visual information? To address these questions, we are using as a model system the primary visual cortex of mice trained in behavioural tasks. The experimental tools we are using are based on cutting-edge methods in Optogenetics, optical imaging, and electrode recording. This research provides an ideal test-bed for understanding the neural mechanisms of visual perception and its outcomes have the potential to provide important clinical applications in the field of cortical visual prostheses.

Main Research Field

Biology

Related Research Fields

Biological Sciences

Keywords

Selected Publications

  • Zoccolan D, Cox D, Benucci A:
    "What can simple brains teach us about how vision works."
    Front Neural Circuits, 9:51, (2015) [Full]
    10.3389/fncir.2015.00051
  • Madisen L, ...,Benucci A, ..., Zeng H:
    'Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.'
    Neuron, Mar 4;85(5):942-58 (2015) [PubMed]
    10.1016/j.neuron.2015.02.022
  • Carandini M, Shimaoka D, Rossi LF, Sato TK, Benucci A, Knöpfel T:
    'Imaging the awake visual cortex with a genetically encoded voltage indicator.'
    J Neurosci, Jan 7;35(1):53-63, (2015) [PubMed]
    10.1523/JNEUROSCI.0594-14.2015
  • Schölvinck ML, Saleem AB, Benucci A, Harris KD, Carandini M:
    'Cortical state determines global variability and correlations in visual cortex.'
    J Neurosci, Jan 7;35(1):170-8, (2015) [PubMed]
    10.1523/JNEUROSCI.4994-13.2015
  • Pisauro MA, Dhruv NT, Carandini M, and Benucci A:
    'Fast hemodynamic responses in the visual cortex of the awake mouse.'
    J Neurosci, Nov 13;33(46), 18343-51 (2013)
    10.1523/JNEUROSCI.2130-13.2013
  • Benucci A, Saleem AB, and Carandini M:
    'Adaptation maintains population homeostasis in primary visual cortex.'
    Nat Neurosci, Jun 16(6), 724-9 (2013)
    10.1038/nn.3382
  • Okun M, ..., Benucci A, ..., Carandini M, and Harris K:
    'Population rate dynamics and multineuron firing patterns in sensory cortex.'
    J Neurosci, Nov 28; 32(48):17108-19 (2012) [PubMed]
    10.1523/JNEUROSCI.1831-12.2012
  • PearsonRA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ,Chuang JZ, Azam SA, Luhmann UF, Benucci A, Sung CH, Bainbridge JW,Carandini M, Yau KW, Sowden JC, and Ali RR:
    'Restoration of vision after transplantation of photoreceptors.'
    Nature, 485(7396), 99-103 (2012)
    10.1038/nature10997
  • Benucci A, Ringach DL, and Carandini M:
    'Coding of stimulus sequences by population responses in visual cortex.'
    Nature Neuroscience, 12(10), 1317-24 (2009)
    10.1038/nn.2398
  • Katzner S, Nauhaus I, Benucci A, et al.:
    'Local origin of field potentials in visual cortex.'
    Neuron, 61:35-41, (2009) [PubMed]
    10.1016/j.neuron.2008.11.016